Description

Overview

Epitalon, also spelled Epithalon, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It was developed from research on pineal peptide preparations and has been investigated in cellular-aging, telomere, circadian, antioxidant, and gene-expression models. Some laboratory studies report changes in telomerase activity and telomere-related endpoints, while human literature is largely composed of older studies from a limited number of research groups. Claims about lifespan extension or reversal of human aging should therefore be avoided.

How It Works

• Telomere biology: Cell-culture research has examined telomerase activity and replicative-senescence endpoints.
• Gene regulation: Peptide-gene interactions and transcriptional effects have been investigated in experimental systems.
• Circadian biology: Research has explored pineal signaling, melatonin rhythms, and age-related circadian changes.

Research Areas

• Cellular aging
• Telomere and telomerase research
• Circadian signaling
• Oxidative-stress models

Research / Study Context

• Cell-culture studies: Human somatic-cell models have been used to examine telomerase and replicative lifespan.
• Aging research: Older animal and human studies explored circadian, immune, and gerontological endpoints.

Key Research Findings

• Laboratory evidence supports continued investigation of telomere-related mechanisms.
• Human evidence is limited and not sufficient to establish anti-aging efficacy.
• The literature should be presented with clear separation between cell, animal, and human findings.

Related Research

• Humanin
• MOTS-C
• NAD+

Scientific Reference Starter Set

• Peptide Education Hub: Epithalon/Epitalon profile
• PubMed search: Epitalon telomerase AEDG
• PubMed search: Khavinson Epitalon aging