PT-141 (Bremelanotide)

Central melanocortin signaling and sexual-response neurobiology

Synthetic melanocortin receptor agonist

Bremelanotide is an FDA-approved active ingredient in Vyleesi; Apex material is research-use-only and is not the approved drug product

Overview

PT-141, also known as bremelanotide, is a synthetic melanocortin peptide that acts centrally on melanocortin receptors, particularly MC4R-related pathways. Unlike phosphodiesterase inhibitors, its principal research mechanism is central nervous-system signaling rather than direct vascular smooth-muscle action. Bremelanotide is the active ingredient in the FDA-approved prescription drug Vyleesi for a specific female sexual-desire indication; that approval does not make a separate Apex research material an approved drug product.

How it works

Melanocortin receptor signaling: Bremelanotide activates central melanocortin pathways involved in arousal and motivated behavior.

Hypothalamic signaling: Research focuses on brain networks involved in sexual response rather than only peripheral blood flow.

Neurobehavioral endpoints: Clinical studies have measured desire, distress, arousal, and tolerability outcomes.

Research areas

Melanocortin neurobiology

Sexual-response pathways

Central nervous-system signaling

Clinical pharmacology

Research / study context

Phase 3 clinical research: Large randomized trials evaluated efficacy and safety in the FDA-approved indication.

Earlier male research: Experimental studies also evaluated erectile and arousal-related endpoints in men, but these are not the FDA-approved indication.

Key research findings

Bremelanotide has established central melanocortin pharmacology.

Its FDA approval is indication- and product-specific.

Apex should not imply that its RUO material is equivalent to Vyleesi.

Scientific reference starter set

Peptide Education Hub: PT-141/Bremelanotide profile

FDA prescribing information: Vyleesi (bremelanotide)

PubMed search: bremelanotide RECONNECT phase 3

Research material

View available specifications and batch documentation in the Apex catalog.

Important

For research use only. Not for human consumption. This profile is educational and does not provide treatment or personal-use instructions.