KPV

NF-kB signaling, inflammatory mediators, intestinal and skin models

Tripeptide Lys-Pro-Val derived from alpha-MSH

Investigational; primarily preclinical

Overview

KPV is the three-amino-acid sequence Lys-Pro-Val derived from the C-terminal region of alpha-melanocyte-stimulating hormone (alpha-MSH). It has been studied for anti-inflammatory activity without the pigmentation-related signaling associated with full-length alpha-MSH. Experimental work has focused on NF-kB signaling, pro-inflammatory cytokines, intestinal inflammation, epithelial transport, and skin models. Most evidence remains cellular or animal-based.

How it works

NF-kB signaling: Experimental studies report reduced activation or nuclear translocation of NF-kB in inflammatory models.

Cytokine modulation: Research has measured TNF-alpha, IL-6, IL-1beta, and related inflammatory mediators.

Epithelial effects: Gut and skin models have examined local transport and barrier-associated inflammatory responses.

Research areas

Intestinal inflammation models

Epithelial barrier research

Skin inflammation

Innate immune signaling

Research / study context

Cellular inflammation models: Researchers have measured cytokines, transcription-factor activation, and epithelial responses.

Animal colitis models: Preclinical studies have evaluated inflammation scores, tissue injury, and local peptide delivery.

Key research findings

KPV has reproducible anti-inflammatory signals in experimental models.

Human clinical evidence is limited.

Claims should remain focused on research pathways rather than disease treatment.

Scientific reference starter set

Peptide Education Hub: KPV profile

PubMed search: KPV alpha-MSH tripeptide colitis

PubMed search: KPV NF-kB inflammation

Research material

View available specifications and batch documentation in the Apex catalog.

Important

For research use only. Not for human consumption. This profile is educational and does not provide treatment or personal-use instructions.