- Metabolic / Amylin Research
Cagrilintide
Satiety signaling, appetite regulation, gastric emptying, and body-weight research
- Compound type
Long-acting amylin analog
- Research status
Investigational clinical-stage compound
- Scientific overview
Overview
Cagrilintide is a long-acting analog of amylin, a pancreatic peptide hormone involved in meal-related satiety and energy-balance signaling. It has been developed for once-weekly clinical research and has been studied both alone and in combination with semaglutide. Unlike GLP-1 receptor agonists, cagrilintide works primarily through amylin/calcitonin-receptor-family signaling. Clinical studies have evaluated appetite, body weight, tolerability, and combination strategies designed to engage complementary metabolic pathways.
How it works
Amylin-receptor signaling: Cagrilintide activates amylin-receptor pathways involved in satiation and meal termination.
Central appetite regulation: Amylin signaling influences brain regions involved in food intake and energy balance.
Gastric and metabolic effects: Research has evaluated effects on gastric emptying and post-meal metabolic regulation.
Research areas
Satiety and appetite signaling
Body-weight research
Combination incretin/amylin research
Metabolic regulation
Research / study context
Phase 2 obesity research: Randomized human studies have evaluated multiple cagrilintide doses against placebo and active comparators.
Combination studies: Cagrilintide has been studied with semaglutide to evaluate complementary amylin and GLP-1 pathways.
Key research findings
Human trials demonstrate pharmacologic activity on appetite and body-weight endpoints.
The compound remains investigational as a standalone research material.
Combination research is a major area of ongoing development.
Scientific reference starter set
Peptide Education Hub: Cagrilintide profile/index
PubMed search: cagrilintide obesity phase 2
ClinicalTrials.gov search: cagrilintide
Research material
View available specifications and batch documentation in the Apex catalog.
Important
For research use only. Not for human consumption. This profile is educational and does not provide treatment or personal-use instructions.