- Metabolic / Dual-Agonist Research
Survodutide
Telomere biology, gene regulation, circadian biology, and aging research
- Compound type
Nine-amino-acid peptide
- Synthetic tetrapeptide Ala-Glu-Asp-Gly (AEDG)
Investigational; limited modern controlled human evidence
- Scientific overview
Overview
Survodutide (BI 456906) is an investigational dual agonist designed to activate both GLP-1 and glucagon receptors. The GLP-1 component targets incretin, appetite, and glucose-regulation pathways, while glucagon-receptor activity is being studied for effects on energy expenditure and hepatic lipid metabolism. Human clinical programs have evaluated obesity and metabolic dysfunction-associated steatohepatitis/liver-fat outcomes. It remains a clinical-development compound.
How it works
GLP-1 receptor signaling: Influences satiety, glucose-dependent insulin signaling, and gastrointestinal pathways.
Glucagon receptor signaling: Research investigates energy expenditure, lipid oxidation, and hepatic metabolism.
Dual-pathway integration: The compound is designed to balance two receptor systems for complementary metabolic effects.
Research areas
Obesity research
Metabolic liver disease
Hepatic fat metabolism
Glycemic and cardiometabolic endpoints
Research / study context
Phase 2 obesity research: Human trials evaluated body-weight change, metabolic markers, tolerability, and dose-response.
MASH/liver research: Randomized trials have evaluated liver histology, liver fat, fibrosis-related endpoints, and metabolic outcomes.
Key research findings
Clinical studies demonstrate strong biologic activity in obesity and liver-metabolism endpoints.
Gastrointestinal adverse effects are common in GLP-1-based research.
Survodutide remains investigational and should not be presented as an approved therapy.
Scientific reference starter set
Peptide Education Hub: Survodutide profile
PubMed search: survodutide BI 456906 obesity
ClinicalTrials.gov search: survodutide MASH obesity
Research material
View available specifications and batch documentation in the Apex catalog.
Important
For research use only. Not for human consumption. This profile is educational and does not provide treatment or personal-use instructions.