Tesamorelin

Pituitary GH/IGF-1 signaling, body composition, and liver-metabolism research

Stabilized GHRH analog

Tesamorelin is an FDA-approved active ingredient in Egrifta products for a specific HIV-lipodystrophy indication; Apex material is RUO and is not the approved drug product

Overview

Tesamorelin is a synthetic growth-hormone-releasing hormone analog modified to improve stability. It activates pituitary GHRH receptors, increasing endogenous growth-hormone release and downstream IGF-1 signaling. FDA-approved tesamorelin products are indicated for reduction of excess abdominal fat in adults with HIV and lipodystrophy. Research has also examined visceral adipose tissue, liver fat, body composition, and metabolic endpoints. Any Apex page should clearly separate the approved branded drug from Apex research material.

How it works

GHRH receptor activation: Stimulates pituitary release of endogenous growth hormone.

GH/IGF-1 axis: Downstream IGF-1 signaling provides a measurable endocrine response.

Adipose and hepatic metabolism: Clinical studies have evaluated visceral fat and liver-related metabolic endpoints.

Research areas

HIV-associated lipodystrophy

Visceral adipose tissue

Liver-fat research

GH/IGF-1 physiology

Research / study context

Randomized HIV-lipodystrophy trials: Clinical studies measured visceral adipose tissue, body composition, IGF-1, and safety.

Liver-fat studies: Research has evaluated hepatic fat and fibrosis-related markers in selected populations.

Key research findings

Tesamorelin has strong human evidence for its approved indication.

Evidence outside that indication varies and should be described as research.

Apex material must not be represented as Egrifta or an FDA-approved substitute.

Scientific reference starter set

Peptide Education Hub: Tesamorelin profile

FDA prescribing information: Egrifta SV/WR

PubMed search: tesamorelin visceral adipose HIV liver fat

Research material

View available specifications and batch documentation in the Apex catalog.

Important

For research use only. Not for human consumption. This profile is educational and does not provide treatment or personal-use instructions.